Canopy Biosciences, a Bruker Company, today announced the launch of a first in a series of assay kits for ChipCytometry™, a quantitative, high dynamic range (HDR) and high-resolution multiplexing technology for spatial proteomics. The Canopy assay kits are validated and optimized for use with the Canopy ZellScannerONE™ instrument to quantitatively image dozens of targeted protein biomarkers simultaneously on a single tissue section at single-cell spatial resolution. ChipCytometry assay kits that are based on Canopy’s extensive experience in their antibody biomarker panels for services will provide researchers with reliable, ready-to-use reagents that have been extensively validated in a variety of tissue types. The release of these assay kits will streamline the user experience with ChipCytometry for a shorter pathway to meaningful biological advances. This first Spatial Immune Profiling Kit is a comprehensive kit for highly multiplexed, quantitative spatial phenotyping of key immune cell populations in human formalin-fixed paraffin-embedded (FFPE) tissues.
“ChipCytometry assays enable us to investigate tissue samples and deeply phenotype cells. The time we spend in our lab optimizing assay conditions can be a challenge,” said Lixin Zhang, M.D., Ph.D., Research Scientist at University of Pittsburgh Magee-Womens Research Institute. “Using pre-validated assay kits saves us precious time that we can spend on other lab activities. The kit will allow us to reliably test more samples in a shorter time frame.”
Edward Weinstein, Ph.D., President at Canopy Biosciences, added: “These assay kits for ChipCytometry provide ready-to-use tools for highly quantitative, high-resolution and multiplexed proteomics studies for immuno-oncology, neuroscience and infectious disease research. Our scientists have extensive experience optimizing combinations of validated antibodies to create the highest quality data. The ChipCytometry assay kits will streamline researchers’ ability to spatially profile the tumor microenvironment, by eliminating time spent on validation.”
ChipCytometry combines high-resolution, high dynamic range imaging with advanced image analysis software to enable quantitative measurements of high-plex protein biomarker assays. The ZellScannerONE instrument is a fully integrated, automated imaging system that produces high-resolution, high-dynamic-range (HDR) images that are analyzed by powerful AI-driven software to quantify protein targets with true single-cell resolution. Using sequential staining and photobleaching on ZellSafe™ microfluidic chips, a virtually unlimited number of biomarkers can be visualized and quantified.
About Canopy Biosciences, a Bruker Company
Canopy Biosciences (canopybiosciences.com) was formed in 2016 and rapidly built a comprehensive portfolio of products and services for spatial biology, multi-omics, and bioprocessing. Canopy offers its ChipCytometry technology for precise spatial multiplexing in cells and tissue samples, along with other technologies of ultrasensitive DNA sequencing (RareSeq), RNA-Seq, and gene expression analysis for services. Canopy Biosciences is headquartered in St. Louis, Missouri, with additional CRO sites in California and Germany to serve researchers at universities, research institutions, and biotechnology and pharmaceutical companies worldwide.