Alongside this development, a high premium on products that are capable of tackling emergent, problematic pathogens will also contribute to changing market dynamics. Estimates reveal that the global prevalence of SFI has risen to 4 for every 1,000 of the global population.
The high incidence of SFI over the years is attributed to the widespread use of broad–spectrum antibiotics, which reduce non–pathogenic bacterial populations that compete with fungi, and the growing number of persons with compromised immune systems caused by acquired immunodeficiency syndrome (AIDS), immunosuppressant drugs, and chemotherapy agents.
New analysis from Frost & Sullivan (pharma.frost.com), Systemic Fungal Infection Therapeutics Market - India, finds that local manufacturers are expected to continue to dominate the SFI drug market due to their output of generic medication, although multinationals are trying to gain a foothold through the introduction of newly patented medication.
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"Early diagnosis of systemic fungal infections has been shown to be critical to treatment outcome," says Frost & Sullivan Program Manager Carole Gaffud. "Advances in diagnostic capabilities are paving the way for more increased usage of targeted therapy for systemic fungal infections; this is reflected in the growing proportion of patients treated definitively in the last five years."
Although key therapeutics have been in the market to treat the most causative pathogen (Candida Albicans), there is still an unmet need to treat more resistant pathogens such as Aspergillus. Despite the advent of more advanced molecular diagnostic technologies, physicians in India continue to use empiric and prophylactic therapies to treat SFI. As more resistant pathogens in systemic fungal infections emerge, treatment is centered on ensuring that the right treatment is administered to the patient.
"Doctors are under pressure to ensure that they identify the most suitable mode of treatment, based on universal criteria, such as risk factors, clinical, radiological, microbiological or other diagnostic evidence," says Gaffud. "The task is made easier for physicians with the growing availability of non-microbiologic and clinical diagnostic techniques, such as Platelia, Fungitell and PNA FISH, to identify the onset of infection."
This places greater emphasis on matching antifungal choice to pathogen susceptibility, increasing the demand for rapid typing of pathogens to ensure informed, targeted drug choices. Consequently, there would be a reduction in the use of prophylaxis in the 'at-risk' patient group and the empiric therapy in, for example, patients in this group with a persistent fever or other suggestive symptoms.
Considering the relatively niche nature of SFI, it is vital for key participants to differentiate their products, especially as advances in diagnostic techniques bring about a restriction of prescriptions to specific therapeutic uses. Therapeutics are shifting away from broad and empiric indications, and pharmaceutical manufacturers need to position their products to address more specific indications defined by pathogen species (and sub species) and patient populations, rather than a broad spectrum. This gives room for a higher degree of differentiation, protecting the specific drug from generic erosion in the future.
The changing epidemiology of causative pathogens has caused the effectiveness of existing therapeutic options to decline. In such a scenario, pharmaceutical manufacturers need to develop drugs that address specific indications, in terms of pathogen coverage and patient groups, that is, solid organ transplant, cancer, neonates, human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS), and surgical patients.
Systemic Fungal Infection Therapeutics Market - India is part of the Pharmaceuticals & Biotechnology Growth Partnership Service program, which also includes research in the following markets: The Systemic Fungal Infection Therapeutics Market in Malaysia, The Systemic Fungal Infection Therapeutics Market in the Philippines, The Systemic Fungal Infection Therapeutics Market in South Korea, The Systemic Fungal Infection Therapeutics Market in Hong Kong, The Systemic Fungal Infection Therapeutics Market in Australia, The Systemic Fungal Infection Therapeutics Market in Taiwan, The Systemic Fungal Infection Therapeutics Market in Singapore, and The Systemic Fungal Infection Therapeutics Market in Thailand. All research services included in subscriptions provide detailed market opportunities and industry trends that have been evaluated following extensive interviews with market participants.
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