Free press releases distribution network?

Agency / Source: The Scott Partnership

Check Ads Availability|e-mail Article


Are you the owner of this article?, Turn it PREMIUM with your LOGO instead - and make it 3rd party Ads-Free! within the next hour!



Wyatt Technology DAWN® HELEOS® MALS Instrument Ensures Protein Reagent Quality in Drug Discovery - Wyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation and software, announces that Pfizer Global R&D, has chosen its DAWN® HELEOS® Multi-Angle Light Scattering (MALS) instrument
Wyatt Technology DAWN® HELEOS® MALS Instrument Ensures Protein Reagent Quality in Drug Discovery

 

PRZOOM - /newswire/ - Santa Barbara, CA, United States, 2009/10/06 - Wyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation and software, announces that Pfizer Global R&D, has chosen its DAWN® HELEOS® Multi-Angle Light Scattering (MALS) instrument.

   
 
Your Banner Ad Here instead - Showing along with ALL Articles covering Medical Services/Equipment Announcements

Replace these Affiliate Programs at ANYTIME! Your banner here within the next hour. Learn How!


 

to monitor protein reagent quality in drug discovery. The instrument’s unmatched analytical capabilities are illustrated in a new application note, titled “Using MALS to Ensure Protein Reagent Quality in Drug Discovery”

Quality and consistency of protein reagents are critical elements to successful drug discovery and development. When targeting a particular protein of interest, the best way to obtain dependable results is to perform different in vitro experiments using a protein with similar biological properties. It is important that molecularity, purity, shape and degree of heterogeneity remain the same regardless of any alterations of the model protein or the formulation buffer. Affinity tags or changes to buffer excipients may also be required.

Traditional characterization techniques, such as plate-based assays and biophysical methods where native proteins are preferred, are not efficient when alterations of solution properties of proteins occur. Crystallization studies, for example, typically have a higher rate of success when the proteins involved are simplified, whether they are truncated or expressed in bacteria to minimize post-translational modifications. MALS overcomes these limitations and has proven a very powerful technique for monitoring solution properties of proteins while changes to reagents are taking place.

The new application note demonstrates how light scattering data can be used to elucidate the solution properties of a protein expressed from two different constructs. The first construct was the shorter of the two, designed for crystallization studies. Experimental results, combined with the fact that the enzyme showed activity and was the predominant species in mass spectrometry, would lead to the erroneous confirmation of the suitability of the reagent. The DAWN HELEOS MALS data, however, showed that the enzyme was very heterogeneous. The second construct, which was designed to address this problem, was the full-length enzyme. In that case, the DAWN HELEOS demonstrated that the protein was in its biologically active form (dimer) and was highly homogenous. This information provided confidence to the project team at Pfizer to move forward with the second construct for crystallography, NMR and HTS studies.

To find out more about the DAWN HELEOS or to obtain a copy of the new application note, please email info[.]wyatt.com

About Wyatt
Based in Santa Barbara, California, Wyatt Technology (wyatt.com) is the world’s leading provider of instruments for absolute macromolecular characterization. With over 40 years’ experience developing multi-angle light scattering detectors, working with customers in the biotechnology, chemical, petrochemical, pharmaceutical, academic and government arenas, Wyatt prides itself on its entrepreneurial spirit, and the uniqueness of its offerings. The Company’s groundbreaking technology and uncompromising levels of customer care make Wyatt the global hallmark in its field.

 
 
Your Banner Ad Here instead - Showing along with ALL Articles covering Medical Services/Equipment Announcements

Replace these Affiliate Programs at ANYTIME! Your banner here within the next hour. Learn How!


 

Agency / Source: The Scott Partnership

 
 

Availability: All Regions (Including Int'l)

 

Traffic Booster: [/] Quick PRZOOM - Press & Newswire Visibility Checker

 

Distribution / Indexing: [+]

 
 
# # #
 
 
  Your Banner Ad showing on ALL
Medical Services/Equipment articles,
CATCH Visitors via Your Competitors Announcements!


Wyatt Technology DAWN® HELEOS® MALS Instrument Ensures Protein Reagent Quality in Drug Discovery

Company website links NOT available to basic submissions
It is OK to republish and/or LINK any newswire for any legitimate media purpose as long as you name PRZOOM - Press & Newswire and LINK as the source.
 
  For more information, please visit:
Is this your article? Activate ALL web links by Upgrading to Press Release PREMIUM Plan Now!
|
Contact: Laura Browne 
+44 1477 539539 wyatt[.]scottpr.com
 
PRZOOM / PRTODAY - Newswire Today disclaims any content contained in this article. If you need/wish to contact the company who published the current release, you will need to contact them - NOT us. Issuers of articles are solely responsible for the accuracy of their content. Our complete disclaimer appears here.
IMPORTANT INFORMATION: Issuance, publication or distribution of this press release in certain jurisdictions could be subject to restrictions. The recipient of this press release is responsible for using this press release and the information herein in accordance with the applicable rules and regulations in the particular jurisdiction. This press release does not constitute an offer or an offering to acquire or subscribe for any The Scott Partnership securities in any jurisdiction including any other companies listed or named in this release.

Medical Services/Equipment via RSSAdd NewswireToday - PRZOOM Headline News to FeedBurner
Find who RetweetFollow @NewswireTODAY



Are you the owner of this article?, Turn it PREMIUM with your LOGO instead - and make it 3rd party Ads-Free! within the next hour!




Read Latest Press Releases From The Scott Partnership / Company Profile


Read Medical Services/Equipment Most Recent Related Press Releases:

Datalogic Announces New Healthcare Memor X3 HC Mobile Computer
Neuronix Ltd Announces the First Group of Mild to Moderate Alzheimer Patients to be Successfully Treated by The NeuroAD™ Therapy System
SelectMDx to be Distributed Across Middle East by IPS Genomix
GE Healthcare Partners with Oritain to Introduce Independent Test to Confirm Country of Origin of Fetal Bovine Serum
Saebo, Inc. Awarded Patent for Low-Profile Stroke Recovery Glove
GE Healthcare and HeartFlow Announce Global Cardiovascular Collaboration
Insulin Delivery Devices Market Size to Expand at 7% CAGR through 2020 Says PMR
PMR Releases Report for Next Generation IV Infusion Pumps Market Impact of Existing and Emerging Market 2017-2025
Medical Tapes Market to Reach US$ 2Bn by 2024 Reports PMR
Global Pyrogen Testing Market Value Expected to Increase to US$ 1.37 Billion by 2024 Says PMR

Boost Your Social Network
& Crowdfunding Campaigns


LIFETIME SOCIAL MEDIA WALL
 
NewswireToday Celebrates 10 Years in Business
Find business coaching, life coaching, executive coaching and corporate coaching, best selling coaching books, ...



PREMIUM Members


Visit  NAKIVO, Inc.

Visit  JobsWare.com

Visit  La Bella Bakery Artisan Bakery Arizona







 
  ©2017 PRZOOM — Limelon Advertising, Co.
Home | About PRZOOM | Advertise/Pricing | Contact | Investors | Privacy/TOS | Sitemap | FRANCAIS
newswire, PR press releases distribution service magazines engine news alert newsroom press room breaking news public relations articles company news alerts newswiredistribution ezine bizentrepreneur biznewstoday digital business report market search pr firms agencies reports distri-bution today investor relation successful internet entrepreneur newswire distribution prtoday.com freenewswiredistribution asianewstoday bizwiretoday USA pr UK today