Besides rapid uptake in the burgeoning fields of molecular diagnostics, epigenetics, pharmacogenomics, and forensics, researchers' quest for faster, more standardized, and higher throughput workflow solutions and the resulting uptake of automated purification systems ensure forward momentum for the market.
New analysis from Frost & Sullivan (drugdiscovery.frost.com), U.S. Nucleic Acid Purification and Isolation Markets, determined that the market earned revenues of $301.9 million in 2007 and forecasts this figure to reach $619.2 million in 2014.
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"The diversity of research fields that require nucleic acid purification indicates that the market will experience growth in several sectors to balance the possible decline in other areas," says Frost & Sullivan Research Analyst Christi Bird. "Currently, suppliers are benefiting from more growing markets than declining ones, and the high growth occurring in the genomic DNA and RNA purification products market has effectively counteracted a stagnant plasmid purification market."
During 2007, the consumables market contributed the lion's share of revenues, which amounted to 72.0 percent of the total NAPI market. The instrumentation segment accounted for 28.0 percent of revenues. However, the increasing number of suppliers in the nucleic acid purification market has resulted in price competition over the years, causing commoditization of widely available products.
Nevertheless, the emergence of applications such as genotyping, molecular diagnostic testing, and expression analysis offer suppliers an opportunity to aggressively develop products with advanced parameters to gain market share and thwart market commoditization.
Another factor impeding growth in this market is the continuing popularity of home-brew methods. Using chemicals such as cesium chloride, phenol, or chloroform for sample purification is more cost effective for laboratories when compared to the purchase of a complete kit. Though there are numerous disadvantages associated with home-brew methods – more manual steps, susceptibility to human error, toxicity, lack of reproducibility and standardization – price remains the crucial factor keeping these methods in practice.
"Academic laboratories with budgetary constraints and inexpensive labor will likely continue to use home-brew methods until funding improves," explains Bird. "Other researchers may opt to use home-brew chemicals and kits interchangeably, depending on the sample type or the quality needed for particular downstream applications."
Nevertheless, NAPI kit vendors maintain that the outlook is optimistic since samples become increasingly precious. Standardization is rapidly growing in importance as inevitable human errors become more costly. Thus, the impact of home-brew methods is expected to eventually taper off with the development and deployment of accurate, less expensive, compact, low throughput instruments.
Overall, suppliers in this space must stay abreast of new trends in downstream technologies, optimizing their kits to suit particular specifications and developing highly specialized products in sync with these emerging applications. Adopting a "one-stop-shop" strategy to allow customers to purchase reagents and instruments for their entire research workflow from a single vendor will also enhance business and expand market share since it simplifies purchasing. This can be achieved through consolidation or partnerships with industry leaders.
U.S. Nucleic Acid Purification and Isolation Markets is part of the Drug Discovery and Clinical Diagnostics Growth Partnership Service program, which also includes research in the following markets: U.S. research ELISA markets, U.S. cell-based assays markets, U.S flow cytometry markets, and U.S. protein expression and purification markets. All research services included in subscriptions provide detailed market opportunities and industry trends that have been evaluated following extensive interviews with market participants. Interviews with the press are available.
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U.S. Nucleic Acid Purification and Isolation Markets