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AnaSpec Introduces New Line of LL-37 GO™ Peptides - LL-37 peptides are AnaSpec’s latest addition to our expansive collection of research-ready, on-demand GO™ Peptides
AnaSpec Introduces New Line of LL-37 GO™ Peptides

 

PRZOOM - /newswire/ - San Jose, CA, United States, 2008/11/26 - LL-37 peptides are AnaSpec’s latest addition to our expansive collection of research-ready, on-demand GO™ Peptides.

   
 
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The LL-37 GO™ collection includes LL-37 fragments consisting of 8-37 and 18-37; FAM, biotin-LC-labeled LL-37 (LC is a 6-carbon linker); and Cys-LC-LL-37 - useful in applications such as conjugation to resin. Sepharose linked LL-37 is available as a custom order. New antimicrobial peptides (AMP) include Dermcidin, DCD-1L and mCRAMP, biotin-LC labeled.

Cathelicidins are cationic peptides that have broad-range antimicrobial activity.1 These peptides belong to the family of anti-microbial peptides which form part of the host’s important innate immunity mechanism.2 In humans, cathelicidins and defensins are expressed in immune cells and at epithelial surfaces.3-5 hCAP18, human cationic antimicrobial protein, with a MW of 18 kD, is the only cathelicidin gene found in humans. 2 The N-terminus of this protein consists of a cathelin-like region (highly conserved among species) and a C-terminal termed LL-37.6-7 An amphipathic alpha-helical peptide, LL-37 plays an important role in the first line of defense against local infection and systemic invasion of pathogens at sites of inflammation and wounds. Cytotoxic to both bacterial and normal eukaryotic cells, LL-37 is significantly resistant to proteolytic degradation in solution.8-9 In addition to having antimicrobial activity, LL-37 has been shown to play a role in chemoattraction, dendritic cell differentiation, mast cell degranulation, cytokine secretion, angiogenesis stimulation, and wound healing.10 In other species, the C-terminal antimicrobial region varies in sizes, sequences and structures. 10

About AnaSpec
AnaSpec is a leading provider of integrated proteomics solutions to the world’s largest biotech, pharmaceutical, and academic research institutions. With a vision for innovation through synergy, AnaSpec focuses on three core technologies: peptides, detection reagents, and combinatorial chemistry.

References:
1. Zanetti, M. et al. J. Biol. Chem. 268, 522 (1993)
2. Lehrer, R. and T. Ganz. Curr. Opin. Immunol. 11, 23 (1999)
3. Ganz, T. Nat. Rev. Immunol. 3, 710 (2003)
4. Zanetti, M. J. Leukoc. Biol. 75, 39 (2004)
5. Chromek, M. et al. Nature Medicine 12, 636 (2006)
6. Zanetti, M. et al. FEBS Lett. 374, 1 (1995)
7. Sorensen, OE. et al. Blood 97, 3951 (2001)
8. Neville, F. et al. Biophys. J. 90, 1275 (2006)
9. Oren, Z., et al. Biochem. J. 341, 501(1999)
10. Gordon, YJ. et al. Curr. Eye Res. 30, 385 (2005)

 
 
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AnaSpec Introduces New Line of LL-37 GO™ Peptides

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Contact: Ping Yang 
408-452-5055 ping[.]anaspec.com
 
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IMPORTANT INFORMATION: Issuance, publication or distribution of this press release in certain jurisdictions could be subject to restrictions. The recipient of this press release is responsible for using this press release and the information herein in accordance with the applicable rules and regulations in the particular jurisdiction. This press release does not constitute an offer or an offering to acquire or subscribe for any AnaSpec, Inc. securities in any jurisdiction including any other companies listed or named in this release.

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