The Thermo Scientific TSQ Quantum Access triple quadrupole mass spectrometer, combined with the Thermo Scientific Aria TLX-4 system, uses TurboFlow and multiplexing technologies to offer the industry's most advanced, most sensitive analytical method for clinical research labs like Ameritox. By implementing this advanced LC-MS/MS method, Ameritox has reduced the amount of time spent on sample preparation and increased its mass spectrometry throughput for forensic and specialty toxicology assessments.
The Thermo Scientific TurboFlow technology uses turbulent flow chromatography to separate analytes from biological matrices prior to MS/MS analysis. Unlike traditional technologies, the TurboFlow method injects the sample directly onto a narrow diameter TurboFlow column. By eliminating extraction, derivitization and evaporation, Ameritox has reduced the lengthy sample preparation time traditionally associated with other methods.
The Aria TLX-4 is the only truly independent, parallel, multi-channel high performance liquid chromatography (HPLC) system in the industry. It utilizes Thermo Scientific Aria Software to manage all aspects of the process and allows as many as four sample batches to run at the same time, each with a unique method. By maximizing this multiplexing system, Ameritox has recognized increased productivity - essentially the output of four separate, parallel LC systems from a single mass spectrometer - and avoided the high capital costs associated with other methods.
"We are very pleased with the performance of the Aria TLX-4 multiplexing system with TurboFlow technology," commented Dr. James Bourland, laboratory director, Ameritox. "With the assistance of the Thermo Fisher Scientific field services staff, we have successfully transferred two high-volume confirmations to LC-MS/MS. As a result, we have realized efficiencies by eliminating extractions and reducing the analysis time and turnaround time.
In addition, the quality and reliability of the LC-MS/MS data is superior to our previous method."
Thermo Fisher Scientific has a comprehensive range of clinical solutions for a variety of applications. Featuring chromatography and mass spectrometry techniques under its premier Thermo Scientific brand, in addition to the Microgenics and Athena specialty brands, the company is now a top-10 player in the clinical diagnostics market. "We are thrilled with the success Ameritox has realized through our comprehensive solution," comments Jeff Zonderman, director LC-MS clinical and toxicology, Thermo Fisher Scientific.
"The benefits derived from the Aria TLX-4 multiplexing system powered by TurboFlow technology, combined with the sensitivity and confidence of the TSQ Quantum Access, set us apart in the marketplace."
Mass Spectrometers are general purpose laboratory instruments. They have not been cleared or approved by the United States Food and Drug Administration, the European IVD Directive or any other agency for diagnostic, clinical or other medical use.
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About Thermo Fisher Scientific
Thermo Fisher Scientific Inc. (thermo.com) is the world leader in serving science, enabling our customers to make the world healthier, cleaner and safer. With annual revenues of $10 billion, we have more than 30,000 employees and serve over 350,000 customers within pharmaceutical and biotech companies, hospitals and clinical diagnostic labs, universities, research institutions and government agencies, as well as environmental and industrial process control settings. Serving customers through two premier brands, Thermo Scientific and Fisher Scientific, we help solve analytical challenges from routine testing to complex research and discovery. Thermo Scientific offers customers a complete range of high-end analytical instruments as well as laboratory equipment, software, services, consumables and reagents to enable integrated laboratory workflow solutions. Fisher Scientific provides a complete portfolio of laboratory equipment, chemicals, supplies and services used in healthcare, scientific research, safety and education. Together, we offer the most convenient purchasing options to customers and continuously advance our technologies to accelerate the pace of scientific discovery, enhance value for customers and fuel growth for shareholders and employees alike.
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