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Trevigen Announces A Highly Sensitive Fluorescent One Hour PARP Inhibition Assay - Until now, commercially available PARP assay kits required multiple steps and were time consuming. Trevigen overcomes these drawbacks with the release of the HT Fluorescent Homogeneous PARP Inhibition Assay
Trevigen Announces A Highly Sensitive Fluorescent One Hour PARP Inhibition Assay

 

PRZOOM - /newswire/ - Arlington, VA, United States, 2008/06/20 - Until now, commercially available PARP assay kits required multiple steps and were time consuming. Trevigen overcomes these drawbacks with the release of the HT Fluorescent Homogeneous PARP Inhibition Assay.

   
 
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Poly(ADP-ribose) polymerase, through ribosylation of nuclear proteins, converts DNA Damage into intracellular signals that actuate either DNA repair or cell death. The development of inhibitors to PARP is of ever increasing interest in the drug discovery community since they can be used as modulators of DNA repair mediated resistance to cytotoxic cancer therapeutics. Until now, commercially available PARP assay kits required multiple steps and were time consuming.

Trevigen overcomes these drawbacks with the release of the HT Fluorescent Homogeneous PARP Inhibition Assay. The fluorescent assay is based on the consumption of NAD+ in the PARP ribosylation reaction where NAD+ not consumed by PARP is subsequently measured by a cycling reaction in which a highly fluorescent molecule is produced; therefore an increase in signal positively correlates to increased PARP inhibition. The subject of a Trevigen patent application, it is a simple assay requiring only 1.5 hours from start to finish. The 96 test assay requires no wash steps, and detects as little as 10% inhibition ofPARP Activity. The assay is ideal for the determination of IC50 values for PARP Inhibitors.

Trevigen, Inc. is a rapidly growing biotechnology company focused on the development of products and technology for cancer research, emphasizing apoptosis, DNA damage and repair, and cancer cell function and behavior. Trevigen has been a long-standing provider of quality reagents and kits for researchers investigating programmed cell death and DNA damage and repair. A logical extension of the focus on cancer research has been the recent development of assays for cancer cell function and behavior including angiogenesis, cell invasion and tumor formation. Currently, the product portfolio contains over 500 products categorized into four processes – Apoptosis, DNA Damage and Repair, Angiogenesis, and Oxidative Stress.

Related Products from Trevigen include PARP and PARG assay kits, PARP enzymes and PARP antibodies.

 
 
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Trevigen Announces A Highly Sensitive Fluorescent One Hour PARP Inhibition Assay

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PARP Inhibition Assay |
Contact: Belinda De Leon - Trevigen.com 
1-800-873-8443 info[.]trevigen.com
 
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IMPORTANT INFORMATION: Issuance, publication or distribution of this press release in certain jurisdictions could be subject to restrictions. The recipient of this press release is responsible for using this press release and the information herein in accordance with the applicable rules and regulations in the particular jurisdiction. This press release does not constitute an offer or an offering to acquire or subscribe for any Trevigen, Inc. securities in any jurisdiction including any other companies listed or named in this release.

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