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Otava Ltd Introduces Heat Shock Protein 90 Focused Library - Otava’s new Hsp90 Targeted Library is a special screening collection containing compounds with predicted Hsp90 inhibiting activity - OtavaChemicals.com
Otava Ltd Introduces Heat Shock Protein 90 Focused Library

 

PRZOOM - /newswire/ - Toronto, Ontario, Canada, 2015/03/20 - Otava’s new Hsp90 Targeted Library is a special screening collection containing compounds with predicted Hsp90 inhibiting activity - OtavaChemicals.com.

   
 
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Nowadays, a number of highly potent and pharmaceutically improved heat shock protein 90 (Hsp90) inhibitors are undergoing clinical trials. However, targeting Hsp90 in cancer patients to achieve a significant therapeutic benefit is still a work in progress. OTAVA offers new Hsp90 Focused Library containing 823 compounds which can be an excellent basis for cancer related research and drug discovery projects.

Hsp90 is a highly abundant and ubiquitous molecular chaperone which plays an important role in the folding of newly synthesized proteins or stabilizing and refolding denatured proteins after stress. Its expression is associated with many types of tumors including breast cancer, pancreatic carcinoma, human leukemia and others. Therefore, Hsp90 inhibition provides important pharmacological platform for anticancer therapy. Also, in the last years, Hsp90 has become an interesting therapeutic target in neurodegenerative disorders, and in the development of anti-virals and anti-protozoan infections.

Otava’s new Hsp90 Targeted Library is a special screening collection containing compounds with predicted Hsp90 inhibiting activity. The library has been carefully designed with combined approach that included application of two independent pharmacophore models and molecular docking. The first model was based on crystal structure of human Hsp90 N-terminal domain (PDB ID: 2YKI). The second one was a 3D-pharmacophore model based on the training set of known Hsp90 inhibitors taken from the ChEMBL database. Common top-scored compounds resulted from application of both models were further docked in crystal structure of human Hsp90 N-terminal domain (PDB ID: 2YK9). Final selection of compounds has been made with docking score cut-off filtering, inspection of intermolecular hydrophobic contacts and hydrogen bonds with key active site’s residues.

 
 
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Otava Ltd Introduces Heat Shock Protein 90 Focused Library

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Contact: Andriy Petrenko - OtavaChemicals.com 
416-549-8030 info[.]otavachemicals.com
 
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IMPORTANT INFORMATION: Issuance, publication or distribution of this press release in certain jurisdictions could be subject to restrictions. The recipient of this press release is responsible for using this press release and the information herein in accordance with the applicable rules and regulations in the particular jurisdiction. This press release does not constitute an offer or an offering to acquire or subscribe for any Otava Ltd securities in any jurisdiction including any other companies listed or named in this release.

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