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Voltage-Gated Sodium Channel Blockers Library from OTAVA - OTAVA Ltd offers new Voltage-gated sodium channel blockers library containing 1630 compounds - OtavaChemicals.com
Voltage-Gated Sodium Channel Blockers Library from OTAVA

 

PRZOOM - /newswire/ - Toronto, Ontario, Canada, 2014/10/22 - OTAVA Ltd offers new Voltage-gated sodium channel blockers library containing 1630 compounds - OtavaChemicals.com.

   
 
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Voltage-gated sodium channels are a class of large integral membrane proteins, composed of a highly processed α subunit and one or several smaller β subunits. The α-subunit forms ion-conducting aqueous pore whereas auxiliary β subunits modify the kinetics and voltage-dependence of channel gating.

Voltage-gated ion channels are implicated in the regulation of synaptic transmission, muscle contraction and hormone secretion in response to membrane depolarization.
It was demonstrated that dysfunction of voltage-gated sodium channels led to the development of a wide range of human pathologies such as inherited epilepsy, migraine, periodic paralysis, cardiac arrhythmia, chronic pain syndromes and others. Therefore, the inhibition of voltage-gated sodium channels could be an effective strategy to prevent the development of these diseases.
OTAVA Ltd offers new Voltage-gated sodium channel blockers library containing 1630 compounds.

The library was designed as a special screening collection comprising compounds with predicted sodium channels blocking activity and selectivity. The compounds have been selected by pharmacophore screening of OTAVA Drug-like Green Collection toward three ligand-based pharmacophore models. The models were generated based on the known sodium channel blockers divided into three groups according to their structural features.

This library comprises drug-like compounds only and provides an excellent basis for drug discovery.

 
 
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Voltage-Gated Sodium Channel Blockers Library from OTAVA

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Contact: Andrey Dmytrenko - OtavaChemicals.com 
416-549-8030 info[.]otavachemicals.com
 
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IMPORTANT INFORMATION: Issuance, publication or distribution of this press release in certain jurisdictions could be subject to restrictions. The recipient of this press release is responsible for using this press release and the information herein in accordance with the applicable rules and regulations in the particular jurisdiction. This press release does not constitute an offer or an offering to acquire or subscribe for any Otava Ltd securities in any jurisdiction including any other companies listed or named in this release.

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