Free press releases distribution network?

Agency / Source: GTCbio - Biopharmaceutical Conference

Check Ads Availability|e-mail Article


Are you the owner of this article?, Turn it PREMIUM with your LOGO instead - and make it 3rd party Ads-Free! within the next hour!



Mark Schnute to Speak at Protein Kinases Drug Design October 24-25 in San Diego - Mark Schnute, Associate Research Fellow at Pfizer To Give a Presentation at the 2nd Protein Kinases & Drug Design Conference - GTCbio.com
Mark Schnute to Speak at Protein Kinases Drug Design October 24-25 in San Diego

 

PRZOOM - /newswire/ - Monrovia, CA, United States, 2013/09/05 - Mark Schnute, Associate Research Fellow at Pfizer To Give a Presentation at the 2nd Protein Kinases & Drug Design Conference - GTCbio.com.

   
 
Your Banner Ad Here instead - Showing along with ALL Articles covering Pharma/BioTech/Nutrition Announcements

Replace these Affiliate Programs at ANYTIME! Your banner here within the next hour. Learn How!


 

Mark Schnute, Associate Research Fellow at Pfizer will give a presentation on “Targeted Covalent-Reversible Inhibitors of Bruton’s Tyrosine Kinase for the Treatment of Autoimmune Disease” at the 2nd Protein Kinases & Drug Design Conference to be held in San Diego, CA on October 24-25, 2013 by GTC.

Targeting of non-catalytic cysteine residues with covalent inhibitors is a powerful strategy for optimizing pharmacologic potency and selectivity on challenging targets such as protein kinases. Nonetheless, concerns over off-target modification of proteins by irreversible covalent inhibitors leading to idiosyncratic toxicity has led to caution in applying this strategy to chronic diseases such as inflammation and autoimmune indication even though these events are rare. The utilization of covalent inhibitors that reversibly form an adduct with the protein cysteine is attractive as they may provide the pharmacodynamic and selectivity benefit with less propensity to form long-lived protein adducts.

Dr. Schnute’s this presentation will describe a strategy to design, optimize and characterize covalent, reversible inhibitors targeting Bruton’s Tyrosine Kinase (Btk) and demonstrate their potential utility towards the treatment of inflammatory and autoimmune diseases. Structure-based drug design was utilized to optimize non-covalent inhibitor contacts within the kinase and guide placement of the covalent reactive group. Subsequent tuning of the reactivity and specificity of the electrophile resulted in the discovery of a class of highly selective Btk inhibitors within the cysteine homolog family. Through this strategy, it was identified that an orally bioavailable, potent and selective small molecule inhibitor of Btk which forms a covalent but reversible adduct with the enzyme as confirmed through enzymology, co-crystal structure analysis and mass spectroscopic characterization. The Btk inhibitor has been shown to be efficacious in several preclinical animal models of arthritis and autoimmune disease. This compound represents a new class of covalent Btk inhibitors which offers promise as a clinical candidate for the treatment of autoimmune and inflammatory diseases.

Kinases, key drivers of malignant transformation and major contributors to a variety of other human pathologies, have emerged as some of the most exciting targets in drug discovery. However, with initial well documented success stories came realization that many hurdles lie in the path of successful development of new drugs, targeting kinase signaling. GTC’s 2nd Protein Kinases & Drug Design Conference (gtcbio.com) will bring together speakers representing world leading academic centers and pharmaceutical companies to discuss how to overcome the many hurdles and answer exciting key questions.

This conference is part of our Protein Discovery Summit 2013, which includes three additional parallel conferences shown below:

• Protein Kinases & Drug Design;
• Protein-Protein Interaction;
• Antibody & Protein Therapeutics;
• Protein Expression, Purification & Characterization.

 
 
Your Banner Ad Here instead - Showing along with ALL Articles covering Pharma/BioTech/Nutrition Announcements

Replace these Affiliate Programs at ANYTIME! Your banner here within the next hour. Learn How!


 

Agency / Source: GTCbio - Biopharmaceutical Conference

 
 

Availability: All Regions (Including Int'l)

 

Traffic Booster: [/] Quick PRZOOM - Press & Newswire Visibility Checker

 

Distribution / Indexing: [+]

 
 
# # #
 

 
  Your Banner Ad showing on ALL
Pharma/BioTech/Nutrition articles,
CATCH Visitors via Your Competitors Announcements!


Mark Schnute to Speak at Protein Kinases Drug Design October 24-25 in San Diego

Company website links NOT available to basic submissions
It is OK to republish and/or LINK any newswire for any legitimate media purpose as long as you name PRZOOM - Press & Newswire and LINK as the source.
 
  For more information, please visit:
Is this your article? Activate ALL web links by Upgrading to Press Release PREMIUM Plan Now!
|
Contact: GTCbio.com 
626-256-6405 infogtcbio[.]gtcbio.com
 
PRZOOM / PRTODAY - Newswire Today disclaims any content contained in this article. If you need/wish to contact the company who published the current release, you will need to contact them - NOT us. Issuers of articles are solely responsible for the accuracy of their content. Our complete disclaimer appears here.
IMPORTANT INFORMATION: Issuance, publication or distribution of this press release in certain jurisdictions could be subject to restrictions. The recipient of this press release is responsible for using this press release and the information herein in accordance with the applicable rules and regulations in the particular jurisdiction. This press release does not constitute an offer or an offering to acquire or subscribe for any GTCbio - Biopharmaceutical Conference securities in any jurisdiction including any other companies listed or named in this release.

Pharma/BioTech/Nutrition via RSSAdd NewswireToday - PRZOOM Headline News to FeedBurner
Find who RetweetFollow @NewswireTODAY



Are you the owner of this article?, Turn it PREMIUM with your LOGO instead - and make it 3rd party Ads-Free! within the next hour!




Read Latest Press Releases From GTCbio - Biopharmaceutical Conference / Company Profile


Read Pharma/BioTech/Nutrition Most Recent Related Press Releases:

Frost & Sullivan Commends Nemaura for Developing Superior Transdermal Drug Delivery Technology Platforms, the Memspatch and Micropatch
Greenphire Sponsors Second Annual Clinical Trial Agreements, Investigator Payments and Fair Market Value Meeting
Genentech’s Gazyva Helped People with Previously Untreated Follicular Lymphoma Live Significantly Longer
BD Announces Adoption of Windows 10 ‘Internet of Things’ for the Pyxis™ ES System
Greenphire Named to Deloitte 2016 Technology Fast 500™
Genentech Showcases New Clinical Data Across a Variety of Blood Diseases at American Society of Hematology 2016 Annual Meeting
BD Collaborates with JDRF to Focus on Extended Wear Innovations for Insulin Infusion Delivery
BD Launches First Syringe Designed for Use with Humulin® R U-500 Insulin
MDxHealth Announces Unique CPT Code Awarded for ConfirmMDx from the American Medical Association
BD MAX™ Vaginal Panel Receives FDA Market Authorization to Detect Most Common Causes of Vaginal Infections

Boost Your Social Network
& Crowdfunding Campaigns


LIFETIME SOCIAL MEDIA WALL
 
NewswireToday Celebrates 10 Years in Business
Find business coaching, life coaching, executive coaching and corporate coaching, best selling coaching books, ...



PREMIUM Members


Visit  La Bella Bakery Artisan Bakery Arizona

Visit  BizJobs.com

Visit  Triggr & Bloom







 
  ©2016 PRZOOM — Limelon Advertising, Co.
Home | About PRZOOM | Advertise/Pricing | Contact | Investors | Privacy/TOS | Sitemap | FRANCAIS
newswire, PR free press releases distribution service magazines engine news alert newsroom press room breaking news public relations articles company news alerts newswiredistribution ezine bizentrepreneur biznewstoday digital business report market search pr firms agencies reports distri-bution today investor relation successful internet entrepreneur newswire distribution prtoday.com freenewswiredistribution asianewstoday bizwiretoday USA pr UK today