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Highly Sensitive SensoLyte® HDACs and HATs Assay Kits for Epigenetics Research - AnaSpec has developed a series of highly sensitive assay kits for the detection of the activities of enzymes involved in epigenetics such as HDAC (Histone Deacetylase), SIRT (Sirtuin) 1 & 2 or HAT (Histone Acetyltransferases)
Highly Sensitive SensoLyte® HDACs and HATs Assay Kits for Epigenetics Research

 

PRZOOM - /newswire/ - Fremont, CA, United States, 2012/12/05 - AnaSpec has developed a series of highly sensitive assay kits for the detection of the activities of enzymes involved in epigenetics such as HDAC (Histone Deacetylase), SIRT (Sirtuin) 1 & 2 or HAT (Histone Acetyltransferases).

   
 
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AnaSpec, EGT Group is pleased to offer a wide selection of highly sensitive HDAC (HDAC, SIRT1 & SIRT2) and HAT (CAF & p300) SensoLyte® assay kits. These assays are fluorimetric, some of which are FRET (fluorescence resonance energy transfer)-based.

Histones are the chief protein components of chromatin. They act as spools around which DNA winds. Covalent modification of histone proteins through acetylation and deacetylation affects chromatin structure and regulates gene expression. Histone hyperacetylation is well correlated with increased transcription, whereas hypoacetylation correlates with transcriptional repression. Histone deacetylases (HDACs), which catalyze the removal of acetyl groups from a ε-N-acetyl lysine amino acid on a histone, act as transcriptional repressors of genes. Histone deacetylases have been grouped into three classes. Class I (HDAC 1, 2, 3, 8) and Class II (HDAC4, 5, 6, 7, and 9) are zinc-containing hydrolase’s enzymes. The third class of deacetylases consists of the members of the sirtuin family of enzymes (Sirt 1 to 7). Inhibitors of HDAC classes I and II are being studied as a treatment for cancer and neurodegenerative diseases such as Huntington’s and Alzheimer’s diseases. The Sirtuin 1 (class III) enzyme represents a target for treatment of age-related diseases and type II diabetes.

Histone acetyltransferases (HATs) enzymes regulate the acetylation of histones and nonhistone proteins. The acetylation of the ε-amino groups of lysine residues present at histone tails correlates largely with transcriptional activation, but it is also involved in DNA replication, DNA repair and protein–protein interactions.

 
 
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Highly Sensitive SensoLyte® HDACs and HATs Assay Kits for Epigenetics Research

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Contact: Cecilia Po - AnaSpec.com 
510-791-9560 cecilia[.]anaspec.com
 
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IMPORTANT INFORMATION: Issuance, publication or distribution of this press release in certain jurisdictions could be subject to restrictions. The recipient of this press release is responsible for using this press release and the information herein in accordance with the applicable rules and regulations in the particular jurisdiction. This press release does not constitute an offer or an offering to acquire or subscribe for any AnaSpec, Inc. securities in any jurisdiction including any other companies listed or named in this release.

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